Urticaria pigmentosa
Urticaria pigmentosa jẹ fọọmu ti o wọpọ julọ ti mastocytosis awọ‑ara. O jẹ arun ti o ṣọwọn ti o ṣẹlẹ nitori ilosoke ninu nọmba awọn sẹẹli mast ninu awọ ara, ti o fa hives tabi egbo nigbati ara ba binu. Awọn àpò pupa tàbí brown maa n hàn lórí awọ ara, ní pàtàkì ní àgbègbè àyà, iwájú, àti ẹ̀yìn. Nigbati awọn sẹẹli mast bá binu (bí àpẹẹrẹ nípasẹ̀ fífọ́ awọ ara, ìfarahàn ooru), wọ́n ń ṣàn histamine púpọ̀, èyí tó ń fa ìbànújẹ́ ara tí ń yọrí sí hives tó wà ní àgbègbè tí ó ń binu, tí a tún mọ̀ sí “ami Darier”.
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ReferencesMastocytosis jẹ ipo kan níbi tí àwọn sẹẹli mast ti ń pọ̀ sí i, tí a sábà máa rí ní ọ̀pọ̀ ẹ̀ka ara bíi awọ ara, ọra inú egungun, àti eto onjẹ. Gẹ́gẹ́ bí Ajo Agbaye fún Ilera (WHO), cutaneous mastocytosis lè pín sí mẹ́ta nínú àwọn oríṣìíríṣìí àkọ́kọ́. Iru àkọ́kọ́ (mastocytomas) jẹ́ ti adáṣe tàbí àwọn ọ̀gbẹ́ díẹ̀ (≤3). Iru kejì (urticaria pigmentosa) ní ọ̀pọ̀ àwọn egbo, tí ó máa wà láàárín 10 sí 100. Iru kẹta fihan ilowosi kaakiri gbogbo awọ ara. Urticaria pigmentosa ni fọ́ọ̀mù tí ó wọ́pọ̀ jùlọ ti mastocytosis cutaneous ní àwọn ọmọde, ṣùgbọ́n ó tún lè hàn ní àgbàlagbà. Ó sábà máa ń jẹ́ ipo tí kò lèwu, tí ó sì máa ń dára sí nígbà ọdún. Kò dàbí mastocytosis àgbàlagbà, urticaria pigmentosa kò ní ipa lórí àwọn ara inú. Ẹ̀ya ara kan ti urticaria pigmentosa ni ìfarahàn rẹ̀ láti fa àwọn àpò kékeré, nyún, pupa‑pupa, tàbí àpò ofeefee‑brown lórí awọ ara, tí a mọ̀ sí hives. Àwọn àpò wọ̀nyí máa ń hàn láti ìgbà kékeré, tí ó sì lè wà ní gbogbo ìgbésí ayé.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Ọmọbirin kan tí ó wà ní ọdún mẹ́fà wá pẹ̀lú ọ̀pọ̀ àwọ̀ dúdú tí ó kọ́kọ́ farahàn lórí awọ̀-òru rẹ, lẹ́yìn náà sì tan sí ojú àti ara rẹ ní oṣù mẹ́fà sẹ́yìn. Ó mẹ́nùbà pé àwọn àwọ̀ náà ń dídè, ń yí padà sí pupa, tí ń ń yún nígbà tí a bá tẹ̀ wọn. Kò ní ìrírí rírú, ìgbagbọ̀, ìgbẹ́ gbuuru, tàbí mímú mímúná, àti àwọn ìtàn ìṣègùn ti ara ẹni àti ti ìdílé rẹ̀ kò pèsè àfihàn tó yẹ. Ní àyẹ̀wò, a rí ọ̀pọ̀ àyè dúdú lórí awọ̀-òru, iwájú orí, ojú, àti ọ̀run, pẹ̀lú àwọn àbùlẹ̀ dúdú tí ó dídè díẹ̀ sí àyà àti ẹ̀hìn. Fífọ̀ àwọn àyè náà ní rọrùn ń jẹ́ kí wọ́n wú àti tún ṣeé yí padà ní àkókò iṣẹ́ju 2, ṣùgbọ́n ààmì àìsàn náà ń dínkù lẹ́yìn iṣẹ́ju 15‑20 (Darier's sign).
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
