Urticaria pigmentosa
Urticaria pigmentosa jẹ fọọmu ti o wọpọ julọ ti mastocytosis awọ-ara. O jẹ arun ti o ṣọwọn ti o fa nipasẹ awọn nọmba ti o pọ ju ti awọn sẹẹli mast ninu awọ ara ti o gbe awọn hives tabi awọn egbo si awọ ara nigbati o binu. Awọn aaye pupa tabi brown ni a maa n rii lori awọ ara, ni deede ni ayika àyà, iwaju, ati sẹhin. Awọn sẹẹli mast wọnyi, nigba ti o binu (fun apẹẹrẹ nipasẹ fifọ awọ ara, ifihan ooru), gbejade histamini pupọ, ti nfa ohun ti ara korira ti o yorisi awọn hives ti o wa ni agbegbe si agbegbe ti irritation, nigbamiran ti a tọka si bi "ami Darier".
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References
Mastocytosis jẹ ipo kan nibiti awọn sẹẹli mast pọ si, nigbagbogbo ti a rii ni ọpọlọpọ awọn ẹya ara bii awọ ara, ọra inu egungun, ati eto ounjẹ. Gẹgẹbi Ajo Agbaye fun Ilera (WHO) , cutaneous mastocytosis ni a le pin si awọn oriṣi akọkọ mẹta. Iru akọkọ (mastocytomas) jẹ ti adashe tabi awọn ọgbẹ diẹ (≤3) . Iru keji (urticaria pigmentosa) pẹlu ọpọ awọn egbo, deede orisirisi lati diẹ sii ju 10 si kere ju 100. Iru ti o kẹhin fihan ilowosi ibigbogbo kọja awọ ara. Urticaria pigmentosa jẹ fọọmu ti o wọpọ julọ ti mastocytosis cutaneous ni awọn ọmọde, ṣugbọn o tun le waye ninu awọn agbalagba. O maa n jẹ ipo ti ko ni ipalara ti o maa n dara si ni igba ọdọ. Ko dabi mastocytosis agbalagba, urticaria pigmentosa ko ni ipa lori awọn ara inu. Ẹya ara ọtọ kan ti urticaria pigmentosa ni ifarahan rẹ lati fa kekere, nyún, pupa-pupa, tabi awọn aaye ofeefee-brown tabi awọn egbo lori awọ ara, ti a mọ nigbagbogbo bi hives. Awọn aaye wọnyi nigbagbogbo han ni igba ewe ati pe o le ṣiṣe ni gbogbo igbesi aye.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Ọmọbirin kan ti o jẹ ọdun 6 wa pẹlu ọpọlọpọ awọn awọ dudu ti o kọkọ farahan lori awọ-ori rẹ lẹhinna tan si oju ati ara rẹ ni oṣu mẹfa sẹhin. O mẹnuba rilara pe wọn dide, yipada pupa, ati nyún nigba titẹ. Kò ní ìrírí ríru, ìgbagbogbo, ìgbẹ́ gbuuru, tàbí mímú mímúná, àti àwọn ìtàn ìṣègùn ti ara ẹni àti ìdílé rẹ̀ kò pèsè àwọn àmì tó yẹ. Ni idanwo, a rii ọpọlọpọ awọn aaye dudu lori awọ-ori rẹ, iwaju ori, oju, ati ọrun, pẹlu awọn abulẹ dudu ti o dide diẹ si àyà ati ẹhin. Fifọ awọn aaye naa ni irọrun jẹ ki wọn wú ati itun laarin awọn iṣẹju 2, ṣugbọn awọn aami aisan naa dinku laarin awọn iṣẹju 15-20 (Darier's sign) .
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
